metformin and pregnancy
Definition of metformin
We will get some information about metformin and pregnancy but first some key terms. It is an oral medicine used for treatment of polycystic ovary syndrome – PCOS. Metformin also used in treatment of type – 2 diabetes.
Polycystic ovary syndrome – PCOS is a disease in which tiny cysts are developed on ovary and ovulation process disturbed. PCOS happened in women in adult age and it is also called endocrine disorder.
Type – 2 diabetes is a disease in which insulin present in blood but do not burn sugar. Blood sugar level remains increased for long period of time. It will damage blood capillaries.
metformin and pregnancy success
It is safe to use metformin before conception. Metformin is also used for the treatment of polycystic ovary syndrome – PCOS and removes conceiving difficulty. This is a fact that it is difficult and harder to conceive with polycystic ovary. Metformin and pregnancy facts study tells us that this medicine plays a vital role in conceiving. Polycystic ovary leads to irregular periods and also disturbs ovulation process. All above mentioned problems may lead to infertility.
Higher blood sugar level and PCOS can coexist. many metformin side effects weight loss is one of them which becomes beneficial in getting conceived.It is very useful the use of metformin which reduced the weight and control blood sugar level. Metformin and pregnancy facts studies proved it is safe and beneficial use of metformin before conception. The question is that is it safe to use metformin in pregnancy. We will further discuss metformin and pregnancy as under.
Metformin and pregnancy
Complete experimental studies and test results proves that metformin have no major harmful effect in pregnancy. Embryo or fetal growth, postnatal or birth development are safe while you are taking metformin. All these studies based on animal experimentation. Pregnant women not very much studies under controlled experimentation.
Gestational diabetes (gdm)is a condition in which a woman without diabetes high blood sugar levels during pregnancy. According to PubMed is a free search engine accessing MEDLINE database of references and abstracts on life sciences metformin also useful in gdm.
According to AU TGA metformin falls in pregnancy category C. there is nothing seen in such drugs that they make malformation during embryo and other child development stages. Have some harmful effects that are reversible with passage of time. All these pharmacological effects may be suspected to cause some minor problem but no major loss to new-born during pregnancy.
US FDA kept metformin in pregnancy category B. which elaborate metformin and pregnancy facts and tells us experimentation only conducted on animals. There are no adequate harmful results found in these studies. No comprehensive studies present on pregnant women against use of metformin during pregnancy. So metformin can be used in pregnancy only if it is very necessary to use. Trimester is a period of three months, especially the duration of pregnancy. It is better to avoid use of metformin during first trimester of pregnancy.
Metformin and breastfeeding facts
According AU and US metformin and pregnancy studies very rare information present on nursing infants. metformin side effects during breastfeeding are mentioned here. Openurl sources tells us avoid if you can use of metformin in breastfeeding.
Contradiction of opinion between AU and US present on breastfeeding and use of metformin. In light of limited studies there no major affects seen upon infants. Mother taken metformin excretes 0.5% medicine in breastfeeding milk. During breastfeeding milk have constant medicine ratio for long period of time. The gap between drug administration and breastfeeding cannot control the flow of medicine to infants.
Metformin can be used if necessary for breastfeeding mother. It can be used with caution during pregnancy and breastfeeding. Metformin and pregnancy studies on limited data shows us use of metformin not completely safe. You can use whole milk or skimmed milk alternatively to infants.